Colloquium Presentation, by Dr. Renate Thienel, on side effects of haliperidol vs. risperidone is schizophrenia treatment.

The School of Psychology is proudly hosting a talk by:

 Prof. Renate Thienel

Priority Centre for Translational Neuroscience & Mental Health Research

University of Newcastle

Title: Differential effects of risperidone vs. haloperidol on brain activation during a working memory task in first episode schizophrenia patients.

Date: Thursday 23^rd May 2013, 12-1pm in Keats Reading Room (AVLG17) (video streaming to AV3 in the Ourimbah library)

If you would like to meet with Dr. Thienel, please contact A/Prof Scott Brown (scott.brown@newcastle.edu.au).

Abstract: Neurocognitive impairments in schizophrenia are common and clinically relevant. The majority of people diagnosed with schizophrenia will experience a significant decline in global, social and occupational function levels in the course of their illness. Amongst the different cognitive domains, memory impairments in particular are regarded as possible intermediate phenotypes of schizophrenia. I investigated whether haloperidol and risperidone - two neuroleptic drugs with differential receptor binding profiles - show distinct impacts on functional networks mediating working memory. Differential effects of first- and second-generation antipsychotics on cognition have been reported before, however most of the previous results where employing disproportionately high doses of haloperidol, with the associated increased risk of unwanted side effects, such as cognitive impairment and extrapyramidal motor side effects. I compared the functional haemodynamic response during an n-back task in first-episode schizophrenia patients on a comparably low to moderate dose of haloperidol versus risperidone. Risperidone treated patients showed stronger activations than haliperidol patients in a cortical network that has previously been associated with this type of working memory task. As the results were controlled for medication dose, and neither side effects nor co-treatment differed between the groups, the results are not likely to be affected by these confounding factors, but rather reflect the drugs different receptor binding profile, such as their differential mesocortical dopaminergic input, and pro-cholinergic properties. On the basis of the behavioural results these differences in activation might represent adaptive processes in order to maintain a sufficient level of performance on the one hand, whilst on the other hand patient’s slower behavioural performance might rest upon a failure to recruit task-relevant brain areas comparably.

Bio: Dr Renate Thienel who graduated in Germany (B.A. [Hons.] M.Psych. [Research], Ph.D. [Dr. rer. nat.] in 2007) currently holds a University of Newcastle Postdoctoral Research Fellowship and is based at the Priority Centre for Translational Neuroscience & Mental Health Research. Renate is affiliated with the Schizophrenia Research Institute and the Hunter Medical Research Institute and is an active member of the Australasian Society of Psychiatric Research. Her research focuses on the aetiologies and the rehabilitation of schizophrenia by studying event related potentials, functional magnetic resonance imaging, magnetic resonance spectroscopy, and diffusion tensor imaging. Renate collaborates with national and international colleagues on various neuroimaging research projects into schizophrenia, the prediction of transition to psychosis, the shared biological basis of schizophrenia, a genetically high risk population (22q11DS), and a novel neuro-feedback procedure to modify brain perfusion using functional magnetic resonance imaging with applications for neurocognitive rehabilitation in schizophrenia and dementia as well as cerebral stroke. Her strong translational approach also includes the creation of a normative database of electroencephalographically recorded sensory auditory memory function in children and adolescents with great potential as a diagnostic tool for the detection of “at-risk mental state”.

Colloquium Presentation: Prof. Polina Golland, MIT, on better ways to investigate fMRI data.

Prof. Polina Golland

Computer Science and Artificial Intelligence Laboratory (CSAIL)
Massachusetts Institute of Technology

Title: Alignment-Free Exploratory Analysis of fMRI Data

Date: Thursday 9^th May 2013, 12-1pm in Keats Reading Room (AVLG17) (video streaming to AV3 in the Ourimbah library)

If you would like to meet with Prof. Golland, please contact A/Prof Scott Brown (scott.brown@newcastle.edu.au).

Abstract: We present an exploratory method for simultaneous parcellation of multisubject fMRI data into functionally coherent areas. Our motivation comes from visual fMRI studies with increasingly large number of image categories. The method is based on a solely functional representation of the fMRI data and a hierarchical probabilistic model that accounts for both inter-subject and intra-subject forms of variability in fMRI responses. The resulting algorithm finds a functional parcellation of the individual brains along with a set of population-level clusters. The model eliminates the need for spatial normalization while still enabling us to fuse data from multiple subjects.

If time permits, I will also discuss our current research in
characterizing the spatial variability of activation patterns across
subjects.

(Joint work with Danial Lashkari, Ramesh Sridharan, George Chen,
Ed Vul and Nancy Kanwisher.)

Bio: I am an associate professor in the EECS Department and the Computer Science and Artificial Intelligence Laboratory (CSAIL) at MIT. My primary research interest is in developing novel techniques for image analysis and understanding. I particularly enjoy working on algorithms that either explore the geometry of the world and the imaging process in a new way or improve image-based inference through statistical modeling of the image data. I am interested in shape modeling and representation, predictive modeling and visualization of statistical models. My current research focuses on developing statistical analysis methods for characterization of biological processes using images (from MRI to microscopy) as a source of information. In this domain, I am interested in modeling biological shape and function, how they relate to each other and vary across individuals.

Good News

The first three months of the year have flown by. Lots of exciting things have been happening in the School both research wise and for students.
Here is an overview of some of the achievements so far.

Student News

Rhiannon Hampton, Erin Campbell, Mathew Marchant, Owen Lello and Julia Dray

Graduation was held on 12 April and saw more than 100 graduates attend the ceremony for the School of Psychology program. The following students were winners of school prizes or university or faculty medals.

Rhiannon Hampton received the University medal, a faculty medal and the APS Prize for best performance in 4th year

Faculty medallists were Erin Campbell, Jonathon Love, Kristen McCarter, Kalyce Howard, Sarah McPhail, Anna Tuyl.

School prizewinners were
The Invinskis Prize for 3rd year - Mathew Marchant
The J A Keats Prize for Quantitative or Cognitive Psychology thesis in 4th year  - Julia Dray
The W H Ward Prize –thesis in Applied Psychology – Undergraduate winner Jane Goodwin and Postgraduate winner – Michelle Condon
The Basic Science Prize for a Pure Science thesis – Erin Campbell
The Ros Gribble Prize in Clinical Psychology – Owen Lello

Jane Wheatley has now completed her Professional Doctorates in Clinical and Health Psychology, and Joanne Wirrell has completed her Professional Doctorate in Clinical Pscychology

Elise Mansfield and Guy Hawkins have submitted their PhD thesis for examination and Rickie-Leigh Elliot has submitted her thesis for the Doctor of Clinical Psychology.

Congratulations everyone!

Staff News
 Our academics to have been busy with numerous publication and other achievements. These include:

Media and Community 
Keith Harris gave the opening talk to start off the very successful Seascape & Beyond Art Exhibition Fundraiser at Merewether Surf Life Saving Club. 

Write-up of high impact journal article with Stefania Paolini and Mark Rubin on the Society for Personality and Social Psychology website: PSP Connections. (10/03/13). Do bad interracial interactions shape our attitudes more than good interracial interactions? Retrieved from http://spsptalks.wordpress.com/2013/03/10/do-bad-interracial-interactions-shape-our-attitudes-more-than-good-interracial-interactions/

Port Waratah Coal Services Grant
Recipient - Dr Sally McFadden. Sceral and Retinal Mechanisms Underlying Regional Changes in Myopia.
This research will determine how important retinal signals and sclera strength are in causing myopia and develop new treatments for myopia.

International Profile
Stefania Paolini has been nominated to be chair of the internationalization committee of the (American-led) Society for the Psychological Study of Social Issues (co-chair with Dr D. Livert, Penn State University) for the period 2013-2015. SPSSI is an association of approximately 3,000 psychologists, allied scientists, and others, who are interested in the application of research on the psychological aspects of important social issues to public policy solutions.

Lauren Harms, Postdoctoral Fellow, has been awarded an Australia Israel Research Exchange Neuroscience Fellowship to spend time in Professor Ina Weiner's lab in the School of Psychological Sciences, Tel Aviv University.  Prof Weiner is a world authority on animal models of psychopathology, and in particular neurodevelopmental models of schizophrenia, based on a well known risk factor, namely, maternal infection.  Lauren is working on similar models in Deb Hodgson's animal lab and hopes to learn about Prof Weiner's methods for assessing latent inhibition in rodents - latent inhibition is impaired in schizophrenia.

Refereed Journal Articles
Published Articles 
Walmsley, B. & McCormack, L. (2013). The dance of communication: Retaining family membership despite severe non-speech dementia. Dementia. Published online before print March 20, 2013, http://dx.doi.org/10.1177/1471301213480359

McCormack, L. & Sly, R. (2013). Distress and Growth: The subjective ‘lived’ experiences of being the child of a Vietnam veteran. Traumatology. http://dx.doi.org/10.1177/1534765613481855

McCormack, L. & Joseph, S. (2012). Psychological distress and growth in humanitarian aid personnel: Making meaning of occupational exposure to war and genocide.  Community, Work and Family, 1-17.  http://dx.doi.org/10.1080/13668803.2012.735478

Sinderberry, B., Brown, S.D., Hammond, P., Stevens, A.F., Schall, U., Murphy, D.G., Murphy, K.C. & Campbell, L. (2013) Subtypes in 22q11.2 deletion syndrome associated with behaviour and neurofacial morphology. Research in Developmental Disabilities, 34(1), 116-125. 

Turner, B., Forstmann, B., Wagenmakers, E.-J., Brown, S.D., Sederberg, S. & Steyvers, M. (2013) A Bayesian Framework for Simultaneously Modeling Neural and Behavioral Data. Neuroimage 

Mobini, S., Mackintosh, B., & Reynolds, S. (2013). Clinical Implications of Interpretation Bias in Social Anxiety: An integrative literature review. Cognitive  Therapy and Research. 37, 173-182.

Matthews, N., Todd, J., Mannion, D., Finnigan, S., Catts, S., & Michie, P.T. (in press) Impaired processing of binaural temporal cues to auditory scene analysis in schizophrenia. Schizophrenia Research (http://dx.doi.org/10.1016/j.schres.2013.02.013)

 Guez D. (2013). A common pesticide decreases foraging success and survival in honey bees: questioning the ecological relevance. Frontiers in Physiology, 4:37. http://dx.doi.org/10.3389/fphys.2013.00037

In Press Articles 
Hawkins, G. E., Rae, B., Nesbitt, K. V., & Brown, S. D. (in press) Game-like features might not improve data. Behavior Research Methods 

Trueblood, J., Brown, S.D., Heathcote, A. & Busemeyer, J. (in press) Not just for consumers: Context effects are fundamental to decision-making. Psychological Science 

Matzke, D., Dolan, C.V., Logan, G.D., Brown, S.D., & Wagenmakers, E.-J. (in press) Bayesian parametric estimation of stop-signal reaction time distributions. Journal of Experimental Psychology: General

Turner, B., Sederberg, P., Brown, S.D., & Steyvers, M. (in press) A note on efficiently sampling from distributions with correlated dimensions. Psychological Methods 

Harris, K. M., McLean, J. P., & Sheffield, J. (in press). Suicidal and online: How do online behaviors inform us of this high-risk population? Death Studies.

Harris, K. M. (in press). Sexuality and suicidality: Matched-pairs analyses reveal unique characteristics in non-heterosexual suicidal behaviors. Archives of Sexual Behavior.

Rubin, M. (in press, accepted 06/02/13). “It wasn’t my idea to come here!”: Ownership of the idea to immigrate as a function of gender, age, and culture. International Journal of Intercultural Relations. http://dx.doi.org/10.1016/j.ijintrel.2013.02.001 [Journal ranked in top third of sociology journals]

Wolfenden L, McKeough  A, Bowman J, Paolini S, Francis L, Wye P, & Puhl, R. (2013, accepted 18/04/13). An experimental investigation of parents and their children’s social interaction intentions toward obese children. Journal of Paediatrics and Child Health [2-yrIF 1.28, ranked 66/115 (ISI middle tier) among pediatrics journals]

Sharip, S, Michie, P, Schall, U, Drysdale, K, Case, V, Sanakarayan, A, Sidi, H, Das, S. Generalization of cognitive training in an Australian sample of schizophrenia patients. Comprehensive Psychiatry (accepted 19 March, 2013).  

Cooper, RJ., Atkinson, RJ., Clark, RA, Michie, PT. Event-related potentials reveal modelling of auditory repetition in the brain.  International Journal of Psychophysiology (accepted 11 Feb, 2013)

Prowse, E., Bore, M., & Dyer, S. (In Press). Eating Disorder Symptomatology and Mindfulness: are they related and what is their influence on Body Image, Identity, Personality and Quality of Life? Clinical Psychologist.
Book Chapters  
McCormack, L. (2012).  Humanitarian Missions. Encyclopedia of Trauma: An Interdisciplinary Guide, SAGE, New York 20-904 (First Edition/Ed: Charles Figley). 

McCormack, L. (2012).  Genocide. Encyclopedia of Trauma: An Interdisciplinary Guide, SAGE, New York 20-904 (First Edition/Ed: Charles Figley).

McCormack, L. (2012).  Governments and NGOs. Encyclopedia of Trauma: An Interdisciplinary Guide, SAGE, New York 20-904 (First Edition/Ed: Charles Figley).

McCormack, L. (2012).  Traumatized Entertainers. Encyclopedia of Trauma: An Interdisciplinary Guide, SAGE, New York 20-904 (First Edition/Ed: Charles Figley).

Broyd, SJ, Greenwood, L-M, Croft, RJ, Dalecki, A, Todd, J, Michie, PT, Johnstone, SJ and Solowij, N.  Chronic effects of cannabis on sensory gating. International Journal of Psychophysiology (accepted 10 April, 2013)

Spotlight on Research: What's in (Half) a Face?

In the School of Psychology's new Spotlight on Research section, we focus on recent research conducted by Dr Darren Burke at our Ourimbah campus (pictured partly and wholly below!): 

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When we recognise someone, we integrate information from across their face into a perceptual whole, and do so using a specialised brain region. Recognising other kinds of objects does not engage such specific brain areas, and is achieved in a much more parts-based way.

In a recent review of the literature, we (Burke & Sulikowski, 2013) investigated how this face-specific mode of perception may have evolved by examining the evidence for face-based holistic processing in other species. A surprisingly wide variety of other animals can recognise each other from their “face”, but for most of these there is either evidence that they don’t do this “holistically” (dogs are an example) or insufficient evidence to claim that they do (typically because the experiments are poorly designed).

There is good evidence that some species of monkey are as affected by turning the face upside down as humans are (which is one index of holistic processing), and one species of monkey (Rhesus macaques) also show evidence of the “composite effect”. The composite effect refers to the fact that people find it difficult to recognise the top half of a face if it is shown lined up with the bottom half of a different face, because we can’t help integrating the two halves into a new whole. People have trouble recognising other primate faces when they are upside down, but only show the composite effect for human faces.

We also suggested that the original evolutionary origin of special holistic face processing might not be to recognise who’s who. There are actually lots of other sources of evolutionary important information in faces that require holistic integration. For example, detecting symmetry, and masculinity/femininity is important for mate-choice decisions, and subtle variations in facial configurations underpin many non-verbal communicative signals.

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For more information about this work, please see the following journal article:

Burke, D., & Sulikowski, D. (2013). The Evolution of Holistic Processing of Faces Frontiers in Psychology, 4 DOI: 10.3389/fpsyg.2013.00011

or contact Dr Darren Burke at Darren.Burke@newcastle.edu.au